Communications

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Publications

Gastroenterology · 2026

The Human Blood Virome Differs in Crohn’s Disease

Lamy-Besnier Q., Theodorou I., Sokol H., De Paepe M., Petit M.-A., De Sordi L., Billaud M., Zhang H., Brot L., Culot A., Abriat G.

Gastroenterology 2026;170(4):815-817 · DOI 10.1053/j.gastro.2025.10.007

Human blood phageome in Crohn’s disease; our pipeline annotated the viral genomes of the study.

Our summary

Looking for new markers for an earlier diagnosis of Crohn’s disease, the study compared the virome of plasma and stool, sampled on the same day, in 15 people with Crohn’s disease and 14 healthy people. At group level, the composition of the blood virome (β-diversity) differs between patients and healthy subjects (p = 0.001), whereas that of the stool virome does not (p = 0.513, not significant): 46 differential viral genomes in blood, against 0 in stool.

Viruses · 2025

High-Performance Genome Annotation for a Safer and Faster-Developing Phage Therapy

Culot A., Abriat G., Furlong K.P.

Viruses 2025;17(3):314 · DOI 10.3390/v17030314

rTOOLS v2 against SEA-PHAGES hand curation on 27 phages.

Our summary

Can a fully automatic pipeline match manual curation? We compared rTOOLS v2, run in fully automatic mode, with SEA-PHAGES hand curation on 27 phage genomes. Manual gene calling kept a slight edge: 1.5 more genes found per phage on average, and 1.2 genes per phage given an erroneous function by rTOOLS as a result. For functional annotation, rTOOLS gave a better annotation for 7.0 genes per phage on average, and SEA-PHAGES for 1.7.

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